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Senior Scientist II, Cancer Biology and Immunology

Company: Pharmacyclics
Location: Sunnyvale
Posted on: January 14, 2019

Job Description:

Pharmacyclics is committed to the development and commercialization of novel therapies intended to improve the quality and duration of life and to resolve serious unmet medical needs for cancer patients. Pharmacyclics is a wholly-owned subsidiary of AbbVie (NYSE:ABBV), a global, research-based biopharmaceutical company. Oncology is a key therapeutic area for AbbVie, with a portfolio consisting of three marketed products and a pipeline containing multiple promising new molecules that are being studied in more than 200 clinical trials for over 20 different types of cancer.

More than 1,200 Pharmacyclics and AbbVie research scientists, clinicians, marketing, operations and corporate professionals work in the San Francisco Bay Area. They combine their expertise in immuno-oncology, stem cells, and cell-signaling with their knowledge of bispecific antibodies, antibody-drug conjugates (ADCs), and covalent-inhibitor technologies to discover and develop novel cancer treatments. Together, we are striving to outsmart cancer.

To learn more about us, please visit us at

Pharmacyclics is seeking a Senior Scientist II, Cancer Biology and Immunology.

General Position Summary/Purposes

Provide strong scientific and technical initiative and hands-on implementation of assay development and new target identification/validation in the fields of hematologic malignancies and immuno-oncology. Conceive and execute novel scientific research or development that achieves projects and area goals. Generate new scientific proposals and lead those efforts. Investigate, identify, develop, and optimize new methods and techniques. Act as a lead scientist in his/her area of expertise and critically evaluate relevant scientific and regulatory advances and integrate this knowledge into research or development programs.

Key Accountabilities/Core Job Responsibilities .

-- Effective hands-on execution: Design and execute in vitro and ex vivo POC studies to validate novel hematologic cancer and immuno-oncology targets. Support SAR activities during hit identification and hit-to-lead optimization.

-- Actively engage in the following areas of investigation: tumor cell proliferation, apoptosis, tumor intrinsic signaling, tumor-immune system interaction and immune suppressive effects driven by various cell populations in the TME.

-- Investigate, identify, develop and optimize new methods and techniques according to project needs. Utilize technical expertise and available information to troubleshoot and resolve key project hurdles when encountered.

-- Organize and document experimental procedures and results in a timely manner. Routinely upload data to Abbvie global database, to facilitate collaboration with cross-site, cross-functional teams.

-- Actively participate in internal and external scientific meetings by presenting and critically evaluating emerging scientific literature to contribute to projects.

-- Prioritize tasks and contribute to a highly motivated and productive research team with a sense of urgency and desire to meet project timelines.

-- Develop productive collaborations and communications with other groups across scientific disciplines.

Required Qualifications:

-- Ph.D with minimum of 4 years of postdoctoral training in immunology/cancer biology or related fields. MS with 10+ years of academic/industry experience or BS with 12+ years of academic/industry experience.

-- Prior working experience in the field of immunology or immuno-oncology.

-- Strong skills in cell-based assay development and standard immunology techniques including isolation and stimulation of primary immune cells, cytokine measurements and immunophenotyping using multi-color flow cytometry.

-- Ability to multitask and work within timelines.

-- Strong track record of peer-reviewed publications and presentations.

-- Effective written and verbal communication skills.

Preferred Experience:

-- Knowledge and expertise in innate immunity and myeloid cell biology is strongly preferred. Expertise in NK cell biology is a plus.

-- Expertise in cancer biology skill sets including gain of function or loss of function techniques to validate targets

-- Experience in using cell biology models to validate compound potency, selectivity and elucidate molecular mechanisms of action

-- Experience working with in vivo tumor or immunological disease models.

-- Proficiency in biological data analysis tools (GraphPad Prism, FACS DIVA, FlowJo, etc) Equal Opportunity Employer Minorities/Women/Veterans/Disabled

Keywords: Pharmacyclics, Sunnyvale , Senior Scientist II, Cancer Biology and Immunology, Healthcare , Sunnyvale, California

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