Company: Pharmacyclics, LLC
Posted on: September 13, 2018
Pharmacyclics is committed to the development and commercialization of novel therapies intended to improve the quality and duration of life and to resolve serious unmet medical needs for cancer patients. Pharmacyclics is a wholly-owned subsidiary of AbbVie (NYSE:ABBV), a global, research-based biopharmaceutical company. Oncology is a key therapeutic area for AbbVie, with a portfolio consisting of three marketed products and a pipeline containing multiple promising new molecules that are being studied in more than 200 clinical trials for over 20 different types of cancer. More than 1,200 Pharmacyclics and AbbVie research scientists, clinicians, marketing, operations and corporate professionals work in the San Francisco Bay Area. They combine their expertise in immuno-oncology, stem cells, and cell-signaling with their knowledge of bispecific antibodies, antibody-drug conjugates (ADCs), and covalent-inhibitor technologies to discover and develop novel cancer treatments. Together, we are striving to outsmart cancer. Director, Preclinical Pharmacology will build, strengthen and lead multiple pharmacology programs at the forefront of modern hematological malignancy and immune-oncology pharmacology. In this role, you will manage preclinical pharmacology and in vivo functions at Pharmacyclics and are responsible and accountable for in vivo and ex vivo pharmacology activities from disease mechanisms, animal model development, PKPD, small molecule drug discovery, IND filing through to MOA and resistance studies of clinical assets, especially in the areas of B cell malignancies and immune oncology. Reporting to the Head of Pharmacology and DMPK and located in Sunnyvale, California, this position will play a key role in our discovery process and will work collaboratively with Chemistry, DMPK, Research Biology, Project Director, Clinical Sciences and Regulatory Departments. The ideal candidate should have extensive experience supporting preclinical pharmacology in drug discovery with a track-record of accomplishments in identifying clinical candidates for drug development programs, ideally in hematological malignancies and/or immune-oncology indications. Responsible to provide in vivo and ex vivo pharmacology expertise and strategy to support oncology discovery and early development projects. Influence cross functional teams to support preclinical development of drug candidate and regulatory submission. Pharmacology and PKPD lead in discovery project towards the selection of IND candidate(s). He/She will build and lead an industrial-leading pharmacology team consisting of PhD scientists and research associates, ensure appropriate allocation of resources, and oversee the process, CRO, and vivarium management. Responsibilities: Leading pre-clinical pharmacology function including managing multiple programs and priorities, studies, external CRO management (including outsourced pharmacology and PD studies), staff and budgets. Executing protocol design, study plan, data analysis/ review/ interpretation, and present study report to support preclinical pharmacology components of project plans Providing leadership to grow pharmacology and in vivo functions and develop career path for the group members. Collaborating with discovery colleagues on the scientific/technical aspects of assigned studies from conception through final report, including protocol development, budget (as appropriate), timelines, sample handling/processing, PD analysis, and PK data analysis/interpretation by collaboration with PK group. Participation on cross functional teams as pharmacology representative to insure proper integration of pharmacology activities into overall project plans Collaborating to demonstrate proof-of-concept studies in animals Champion on problem solving and addressing critical need and advancing project. Establishing and characterizing new models and investigating mechanism of action Responsible for life portion of all PK studies, build PK/PD/efficacy correlation Ability to lead and work with others in a positive and collaborative manner in a team-oriented environment. Qualifications: Doctoral degree (Ph.D., D.V.M. or M.D.) in pharmacology, cancer biology, immunology, or a related science and 12 or more years of related experience in the pharmaceutical or biotechnology industry Proven expertise in oncology and cancer drug discovery and development experience; project or department leadership of an industry-based oncology drug discovery or development program. Strong knowledge and working experience in various cancer animal models Ability to work effectively independently and in multi-disciplinary teams, with peers, and with senior management to move projects forward Must have been directly involved with successful IND filings Ability to think critically and solve problems Ability to navigate and be successful in a fast-paced, highly-matrixed work environment Strong research experience in molecular mechanisms and molecular biology techniques Experience in leading a pharmacology laboratory/vivarium. Direct working experience with IACUC protocols and ALACC regulation a must. Experience in cell signaling pathway and immuno-oncology is a plus. Strong leadership, influencing, and inter-personal skills. Ability to work independently to drive project forward as well as collaboratively in a multidisciplinary team environment. Must have clear and effective communication skills and building effective technical collaborations in a team model environment. Equal Opportunity Employer Minorities/Women/Veterans/Disabled
Keywords: Pharmacyclics, LLC, Sunnyvale , Director, Pharmacology, Executive , Sunnyvale, California
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